Hot-melt extrusion (HME) bụ usoro guzosiri ike nke ejirila kemgbe mmalite 1930s, ọkachasị n'ichepụta plastik…
Enwere ụdị extruders abụọ: otu na ejima ịghasa extruders.A na-eji ihe ndị na-emepụta ihe na-emepụta ihe na-emepụta ihe na-emepụta ihe maka ịgbaze na ibuga polymers iji mee ka ha ghọọ ọdịdị na-aga n'ihu, ebe a na-eji ejima screw extruders mee ihe maka polymer-agwakọta ihe ndị ọzọ (pigmenti, fillers, reinforcers, and APIs), na maka devolatilization.Na mmepụta nke usoro ọgwụ, nke chọrọ homo-emesapụ aka na ngwakọta na-agbanwe agbanwe nke ọtụtụ ihe mmepụta ihe, a na-ahọrọ ejima ịghasa extruder n'ihi na ntụgharị nke skru inter-meshing na-enye ngwakọta ka mma iji mepụta otu ihe siri ike nke nwere ezigbo anụrị API, ma ọ bụ. ngwọta siri ike nke API na polymer.Nke a nwere ike imeziwanye ọnụego mgbasa na ike bioavail nke usoro API na-esighị ike nke mmiri na-adịghị mma.API nkesa n'otu n'otu bụkwa ihe achọrọ maka imepụta ngwaọrụ na-ekpochapụ ọgwụ nwere mmeghari intra- na inter-batch nke ki-netics mwepụta ọgwụ.
A na-arụzu mgbaze site na ikpo ọkụ na-ekpo ọkụ n'ime gbọmgbọm ahụ, yana maka ndị na-ekpochapụ ejima na-ekpo ọkụ, dị ka ihe ndị ahụ na-akwacha n'etiti skru na-atụgharị na n'etiti skru na mgbidi nke gbọmgbọm ka a na-ebuga ha.A na-ekpokwa gbọmgbọm ahụ ọkụ na ihe ndị na-ekpo ọkụ na-agbanye na gbọmgbọm ahụ, ma ọ bụ mee ka mmiri dị jụụ.The gbọmgbọm sec-tion okpomọkụ na-emekarị kacha-mized nke mere na viscosity nke gbazee dị ala nke na-ekwe ka con-veying ala gbọmgbọm na kwesịrị ekwesị ịgwakọta, ebe na-edebe tempera-tures ala iji zere thermal mmebi nke ihe.
Ihe nkedo nke ejima ịghasa extruder na-abụkarị inye ụdị ngwakọta na ọnọdụ nnyefe dị iche iche na mpaghara dị iche iche na gbọmgbọm.N'oge mmepe ngwaahịa, skru modular nwere ọtụtụ ele-ments dabara n'otu ogwe aka, na-enye ohere ịkwa akwa na nkwalite nke ịghasa imewe maka ngwaahịa ọ bụla.Enwere ike ịmepụta akụkụ nke ịghasa iji mee mbelata nha nha, ịgwakọta na ibuga ọrụ.A na-ahọrọ ogologo nke ịghasa n'ihe gbasara dayameta gbọmgbọm (nha L / D) iji bulie ogo nke ngwakọta na ọnụ ọgụgụ nke mpaghara achọrọ iji nweta njirimara ngwaahịa ikpeazụ.Ihe atụ nke skru modular zuru oke.Enwere ike wuo skru mmepụta otu otu ka ọ bụrụ otu ihe ahụ dị ka skru mmepe, mana ọ dị mfe ihicha maka nnabata cGMP.
Oge nzipu: Jun-03-2017